Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production
Abstract Background P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes.Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/or impaired steroidogenesis.POR mRNA expression is up-regulated when mesenchymal stem cells (MSCs) differentiate into steroidogenic